A leopard seal has a build suited to pursuit hunting in cold water. The body is long and muscular, and the fore-flippers are proportionally long, which helps the animal turn and accelerate when chasing prey. Adults measure roughly 2.4 to 3.5 metres in length. Females are the larger sex: males average close to 3 metres and about 300 kilograms, while large females can exceed 3.5 metres and weigh more than 500 kilograms.
The head and jaws are the most distinctive features. The gape is wide, and the canine teeth are long, reaching up to about 2.5 centimetres. Behind the canines, the cheek teeth are lobodont, meaning they carry several sharp cusps that interlock when the jaws close. This design lets the seal strain krill from a mouthful of water, the same sieving mechanism found in its close relatives the crabeater, Weddell, and Ross seals. Sensitive whiskers, or vibrissae, help detect prey, and a layer of blubber provides insulation and an energy store in near-freezing seas.