The wild axolotl is Critically Endangered, with recent surveys suggesting fewer than 1,000 — possibly as few as 50 — remain. The causes are all human: Mexico City's growth swallowed the old lakes, and the surviving Xochimilco canals carry sewage, industrial runoff, and pesticides that pass easily through the axolotl's permeable skin. Non-native tilapia and carp, introduced in the 1970s, eat its food, eggs, and young.
The paradox is that millions of axolotls live in labs and the pet trade, but those animals are inbred and genetically distinct from the wild lineage, so they are not a substitute for the wild population. Conservation focuses on breeding wild-type genetics, building filtered "refuge" canals in Xochimilco, and encouraging pesticide-free farming to restore water quality.